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Scientists are revolutionizing biotechnology: artificial cells in focus!
The University of Munich is researching BioSysteM: Innovative approaches to designing biological systems and sustainable technologies.
Scientists are revolutionizing biotechnology: artificial cells in focus!
The Cluster of Excellence BioSysteM has set itself the goal of researching the targeted design and control of biological systems. This innovative approach, summarized under the term “engineering biology,” stands out from traditional synthetic biology. While the latter often aims at creating new biological organisms, BioSysteM focuses on the design of molecular building blocks such as proteins and DNA to fulfill specific tasks. This opens new perspectives for the development of complex biological systems, including artificial cells and molecular machines, that can transform in various application areas.
A central aspect of the cluster's research is the role of artificial intelligence (AI). AI helps scientists recognize complicated patterns and suggest optimal designs for new proteins. This is particularly significant because constructing new systems at the molecular level requires a deep understanding of both biological and engineering principles. The interdisciplinary collaboration between biophysics, biochemistry, molecular biology, bioengineering, computer science and medicine is considered essential.
Interdisciplinarity in training and research
In the context of training, the “Synthetic Biology” course at the Technical University of Darmstadt is noteworthy. This English-taught degree program combines engineering sciences with molecular biology and enables students to equip biological cells with new molecular functions. The focus is on practical laboratory work as well as an understanding of mathematical modeling of biological systems. This promotes creative and innovative thinking, which is essential for solving biological problems.
The curriculum also offers the opportunity to transfer learned knowledge into your own research projects. The students receive comprehensive support through training in intercultural and scientific communication, which prepares them optimally for future challenges in this interdisciplinary field.
Biointelligence as a new paradigm
In parallel with developments in synthetic biology, the concept of biointelligence is becoming increasingly important. This idea is based on the convergence of life sciences, engineering and computer science. Systematically developed biointelligent systems, which include technical and biological components as well as feedback loops, can have characteristics that can be described as intelligent. The goal of such systems is a sustainable design of both products and production processes in vital areas such as health, nutrition, energy and housing.
A biointelligent system is recognized as such if it uses biological resources proactively and works in harmony with the natural environment. These principles are in line with the objectives of BioSysteM, which also include sustainable bioproduction and materials science. Projects such as the development of bioinspired sensors demonstrate the potential of this research area.
Finally, public relations is an essential part of these efforts. Through the “Biomolecular Design Studios”, in collaboration with the German Museum, the public is included in open discussions about the risks and opportunities of research. Support in these reflections is provided by sociologists of science and technology such as Ruth Müller, who shed light on the social contexts of the research.
Overall, it shows that combining evolutionary principles with AI and rational design creates a new research paradigm that could be crucial for the future development of biology and its applications. As the science-based perspective evolves, the commitment to social responsibility and sustainable innovation remains at the forefront.