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Revolutionary cancer research: Magdeburg chemists synthesize disorazol Z1
Chemists at the University of Magdeburg have outdone themselves with the first synthesis of disorazol Z1, a potential cancer therapeutic.
Revolutionary cancer research: Magdeburg chemists synthesize disorazol Z1
Chemists at Otto von Guericke University Magdeburg have made remarkable progress in synthetic chemistry. For the first time, they have synthetically recreated the active ingredient disorazol Z1, a novel molecule with strong cytotoxicity that inhibits the division of human and animal cells. This discovery is made by the team led by senior professor Dr. Dieter Schinzer led and represents a significant step in research into potential cancer therapies. unimagazin.ovgu.de
The active ingredient is produced by myxobacteria, which are often found in organic waste. These bacteria have long proven to be a valuable source for the discovery of new natural products that can be used to develop innovative medicines. The scientists discovered the specific bacterial strain, isolated the active ingredient and examined it for its medicinal properties. nature.com
Challenges and progress
The synthesis of disorazol Z1 was particularly challenging as it is the first total synthesis of this compound. Only two milligrams of the active ingredient were produced during chemical synthesis to avoid health risks. Through the synthesis, targeted modifications of the compound can be made in order to optimize its biological properties. A central goal is to change the molecule so that it specifically docks onto tumor cells and triggers cell death (apoptosis). publications.sulb.uni-saarland.de
Modern chemical techniques and innovative strategies were used to confirm the structure of the compound. The project was financed with around 1.7 million euros from state funds and the European Regional Development Fund (ERDF). The next steps include patenting and publishing the discovery, followed by further research into the drug's medical applicability.
The role of myxobacteria in natural product research
Myxobacteria represent a fascinating and rich source for the discovery of new natural products because they utilize various atypical reactions in their biosynthetic pathways. Recently, three new classes of natural products have been discovered using methods such as active, planned isolation and genome mining: myxoquaterins, myxoglucamides and myxopentacins. These classes show novel structural features and promising bioactive properties. nature.com
In the academic community, myxobacteria are considered to have a promising role in the development of new pharmaceuticals. Their ability to produce innovative metabolites opens up new possibilities in natural products research. Scientists view the further development of this compound as a crucial step for future therapeutic applications and as an answer to the growing challenges of fighting cancer.