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Five new risk factors for uterine cancer discovered!
International study by the MHH discovers five new risk factors for uterine cancer and improves genetic risk prediction.
Five new risk factors for uterine cancer discovered!
An international study led by the Hannover Medical School (MHH) has identified new genetic risk factors for endometrial cancer. This gynecological cancer, which affects approximately 400,000 women worldwide each year, has a high mortality rate of 100,000 deaths. The study aimed to find genetic risk factors at the DNA level that can lead to tumor development in the uterine lining.
Previously known risk factors included obesity, diabetes, increased estrogen levels and advanced age. It is estimated that only 5% of cases are genetic, such as conditions such as Lynch syndrome or Cowden syndrome.
New genetic discoveries
The study identified five new genetic predispositions that are associated with a higher risk of endometrial cancer. To do this, the genetic data of over 17,000 patients with endometrial cancer and around 290,000 healthy women were compared. The results were also checked on other participants from the MHH women's clinic.
A total of five new genomic locations with a high probability of causing cancer were discovered. These results were published in the scientific journal “eBioMedicine”. With these new findings, the number of known genomic risk factors for endometrial cancer increases from 16 to 21.
The NAV3 genetic test
Particularly highlighted was the NAV3 gene, which was identified as a potential tumor suppressor. Silencing this gene led to faster cell growth, while excessive activity led to premature cell death. Understanding the role of this gene could provide new approaches for preventive strategies and therapies.
The main aim of the study was to develop a more accurate risk prediction for hereditary uterine cancer. The NAV3 genetic test is considered a promising candidate for further investigation. This study is funded by the Wilhelm Sander Foundation and brought together institutions from several countries, including Australia, Belgium, China, Germany, Great Britain, Israel, Italy, Canada, Kazakhstan, Sweden and the USA.
With the results of this extensive study, improved screening and treatment approaches for endometrial cancer patients could be developed in the future, which could significantly improve the prospects of the women affected.