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Obesity and heart health: New findings from Cologne!
Dr. Martin Mollenhauer and his research team at the University Hospital of Cologne reveal connections between obesity, myeloperoxidase and cardiovascular diseases.
Obesity and heart health: New findings from Cologne!
A research team led by Dr. Martin Mollenhauer from the Heart Center at the University Hospital of Cologne has discovered significant connections between obesity and cardiovascular diseases. These findings could have far-reaching implications for the treatment of obese patients.
A recent study found that elevated levels of the enzyme myeloperoxidase (MPO) correlate with poorer vascular function in obese patients and in associated mouse models. Loud uni-koeln.de MPO influences the so-called vascular function by changing the functional properties of the perivascular adipocytes in the perivascular adipose tissue (PVAT). This discovery was published in the journal Cell Reports Medicine.
The role of myeloperoxidase and obesity
Myeloperoxidase is active in the PVAT around the aorta in people with obesity and promotes inflammatory processes. This inflammation weakens the protective mechanisms of the blood vessels. Animal models showed that mice without MPO had better vascular function and fewer inflammatory signs in PVAT. There was also an increased release of the hormone adiponectin, which is known to have protective properties for the blood vessels.
The research results suggest that inhibiting MPO could potentially represent a promising therapeutic option for obese people at increased cardiovascular risk. Dr. However, Mollenhauer emphasizes that further studies are necessary before such therapies can be used clinically.
Obesity and Metabolic Health
Obesity often leads to metabolic disorders such as hyperglycemia, hyperlipidemia and increased blood pressure. Still there is loud aerzteblatt.de also the group of “healthy fat people” who, despite being overweight, do not have any metabolic abnormalities. On the other hand, there are also “slim people” who, despite being of normal weight, have an increased risk of cardiovascular diseases.
A large research project, the Nurses Health Study, shows that obese women with a body mass index (BMI) of 30 or more have a 39 percent increased risk of cardiovascular disease (CVD), even if they are metabolically healthy. This increased risk factor also exists if there are no abnormal blood pressure, sugar or lipid levels.
Long-term follow-up of women who participated in the study also shows that 84 percent of metabolically healthy obese women developed metabolic disorders within 20 years. This suggests that obesity, even in the absence of metabolic abnormalities, represents a significant risk of cardiovascular disease.
Overall, this research brings to light important findings that are relevant to both the prevention and treatment of obesity and related cardiovascular diseases. Adopting a healthy lifestyle and maintaining long-term metabolic health are crucial to minimizing associated risks.